Table 1.

Φ_f-values for GCN4-p2′ folding

Substitution	Dimeric Φf value	Cross-linked Φf value
A7G	0.07  ±  0.03	0.74 ±  0.02 (2.8 M, 5.6 M)
A14G	0.16  ±  0.04
S14A		0.54 ±  0.05 (4.5 M, 6.5 M)
A24G	0.25  ±  0.01	0.003 ±  0.05 (2.8 M, 5.3 M)
AAA:GGG	0.46  ±  0.02	0.40 ±  0.02 (2.5 M, 4.5 M)
AAA:TTT	0.51  ±  0.03	0.57 ±  0.02 (3.5 M, 6 M)
AAG:GGG	0.72  ±  0.02	0.73 ±  0.02 (2.5 M, 4.5 M)

Calculated according to Φ_f = −ΔΔG‡_f/(ΔΔG‡_u − ΔΔG‡_f). The ΔΔG‡_f and ΔΔG‡_u values are calculated at 0.9 and 3.5 M GdmCl, respectively, for the dimeric version and at the concentration noted in parentheses for the crosslinked version, to reduce extrapolation errors and sensitivity to slight differences in m values.