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. 1999 Sep 14;96(19):10705–10710. doi: 10.1073/pnas.96.19.10705

Figure 1.

Figure 1

Figure 1

Sequence and RNA analysis of SC-1. (A) Full-length amino acid sequence of the rat SC-1. The PR domain is indicated in italics. The zinc fingers are underlined. (B) Schematic representation of the SC-1 amino acid sequence. Six zinc fingers are located at the COOH terminus. Two serine-rich regions are indicated by steepled boxes, a proline-rich region is indicated as the squared box, and the PR domain is indicated. Below, a schematic representation of the original yeast clone coding sequence is shown for comparison containing amino acids 490–814 (truncated SC1). (C) Northern blot of SC-1 mRNA in adult rat tissues (20 μg total RNA). The blot was stained with methylene blue to visualize the amount of RNA loaded onto each lane (Lower). (D) SC-1 and p75 receptor mRNA expression in cultured Schwann cells and PC12 cells (10 μg total RNA each lane). Lanes: 1, proliferating Schwann cells; 2, quiescent Schwann cells; 3, PC12 cells. (E) An alignment of the PR domains from SC-1, Blimp, RIZ, evi1, and egl-43. The identical amino acids are boxed and shaded. Dashes indicate sequence gaps.