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. 2006 Oct 27;7(12):1206–1210. doi: 10.1038/sj.embor.7400834

Figure 1.

Figure 1

Model of MDC1-regulated phosphorylation of histone H2AX. (1) The MRE11, RAD50 and NBS1 (MRN) complex binds DNA ends at sites of DNA damage and recruits ataxia telangiectasia mutated (ATM), which phosphorylates proximal H2AX. (2,3) Mediator of DNA damage checkpoint 1 (MDC1) binds phosphorylated proximal H2AX and recruits more MRN–ATM. The new pool of ATM phosphorylates more distal H2AX. These events could contribute to the ‘spreading' of H2AX phosphorylation to more distal chromatin regions.