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Interchromosomal interaction between the interferon-γ and Th2 loci revealed by fluorescence in situ hybridization. CD4+ naive T cells were hybridized with a SpectrumGreen-dUTP-labelled probe for the interferon-γ (Ifnγ) locus and a rhodamine–dUTP-labelled probe for the Th2 locus. 4′,6-diamidino-2-phenylindole (DAPI) staining of nuclei shows the presence of DNA. Figure courtesy of R. Flavell and co-workers (Spilianakis et al, 2005).
