Figure 3.

The effect of exercise on weight gain (a) and serum creatine kinase levels (b) in γ-sarcoglycan-deficient muscular dystrophy. (a) gsg^−/− animals were weighed at the end of each week of exercise. The percent increase in weight compared with the starting weight for each genotype was calculated. The mean ± SEM is shown. gsg^−/− animals gained significantly more weight than normal controls (∗, P < 0.05 for weeks 4–7) over the course of the protocol. (b) Serum creatine kinase levels were measured 2 days after completion of the 7-week swimming protocol. The mean ± SEM is shown. Animals lacking γ-sarcoglycan failed to show an increase in creatine kinase that was consistent with a change in the overall amount of degeneration occurring in skeletal muscle.