Abstract
Phenoxybenzamine was injected into the carotid artery of 23 patients after operations on their cerebral arterial aneurysms. Rapid improvement was seen in three cases with pronounced neurological disability. The other 20 were treated prophylactically in an attempt to prevent the onset of spasm. These results would appear to indicate that intracarotid phenoxybenzamine may be of value in the treatment of cerebral arterial spasm, provided that it is given before irreversible infarction of the brain has occurred. Until more is known about its action it would be best to give the drug only after operation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DUFF R. S., GINSBURG J. Some peripheral vascular effects of intra-arterial dibenyline in man. Clin Sci. 1957 Feb;16(1):187–196. [PubMed] [Google Scholar]
- Fraser R. A., Stein B. M., Barrett R. E., Pool J. L. Noradrenergic mediation of experimental cerebrovascular spasm. Stroke. 1970 Sep-Oct;1(5):356–362. doi: 10.1161/01.str.1.5.356. [DOI] [PubMed] [Google Scholar]
- LENDE R. A. Local spasm in cerebral arteries. J Neurosurg. 1960 Jan;17:90–103. doi: 10.3171/jns.1960.17.1.0090. [DOI] [PubMed] [Google Scholar]
- MCHEDLISHVILI G. I. VASCULAR MECHANISMS PERTAINING TO THE INTRINSIC REGULATION OF THE CEREBRAL CIRCULATION. Circulation. 1964 Oct;30:597–610. doi: 10.1161/01.cir.30.4.597. [DOI] [PubMed] [Google Scholar]
- Nelson E., Rennels M. Innervation of intracranial arteries. Brain. 1970;93(3):475–490. doi: 10.1093/brain/93.3.475. [DOI] [PubMed] [Google Scholar]