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. 1971 Feb 27;1(5747):479–482. doi: 10.1136/bmj.1.5747.479

Analgesic Nephropathy: Clinical Syndrome and Prognosis

R M Murray, D H Lawson, A L Linton
PMCID: PMC1795214  PMID: 5101354

Abstract

Over a five-year period 86 patients presented to a renal unit with a history of prolonged analgesic abuse and no other obvious cause of renal damage. Anaemia and peptic ulceration were common, and neurological states suggestive of chronic analgesic intoxication occurred in 22 patients. Thirty-two patients died during follow-up, but the prognosis was much better in patients who ceased abuse of compound analgesics, and improvement could occur even in advanced renal failure. While 84 patients had taken mixtures containing both aspirin and phenacetin, papillary necrosis was also found in two patients who had abused only aspirin, and when phenacetin was withdrawn from several leading compound analgesics, renal function continued to deteriorate in patients ingesting those preparations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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