Table 2.
Mice | Iron absorption, % total 59Fe dose absorbed | Iron distribution
|
Plasma iron turnover, μg/dl/min
|
||
---|---|---|---|---|---|
Organ | % 59Fe absorbed | Before phlebotomy | After phlebotomy | ||
Cp+/+ | 16 ± 6 | Liver | 9 ± 1 | 1.6–2.3 | 3.4–4.2 |
Spleen | 1 ± 0.1 | ||||
RBC | 50 ± 5 | ||||
Cp−/− | 12 ± 3 | Liver | 10 ± 2 | 2.2–2.6 | 1.6–2.2 |
Spleen | 1 | ||||
RBC | 52 ± 4 |
Values are means ± standard deviations, n = 6 from each group. Plasma iron turnover was determined in Cp+/+ and Cp−/− mice before and after 7 days of serial phlebotomy. A significant difference was observed in plasma iron turnover between Cp+/+ and Cp−/− mice after phlebotomy (∗, P < 0.005).