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Transduction of PDHs by recombinant DHBV. PDHs were infected with rDHBV-GFP, a recombinant DHBV in which the S gene was replaced by a GFP gene (see Fig. 1). GFP expression demonstrates transduction of 80 to 90% of the hepatocytes (resulting from infection for 24 hr at an moi of 100 vp per cell) at day 6 p.i. (×100).
