Table 4.
Slc26a4+/+ | Slc26a4-/- | |||||||
No. | Gene | Description | Intensity | P | Intensity | P | Fold | Direction |
1 | Pres | Prestin | 53 | 0/3 | 8 | 0/3 | ||
2 | Kcnq4 | K+ channel | 160 | 0/6 | 160 | 0/6 | ||
3 | Atp2b2 | PMCA2 | 35 | 0/9 | 116 | 3/9 | ||
4 | Calb1 | Calbinin 28K | 53 | 0/12 | 36 | 0/12 | ||
5 | Calb2 | Calretinin | 28 | 0/3 | 27 | 0/3 | ||
6 | Ache | Acetylcholinesterase | 57 | 0/3 | 5 | 0/3 | ||
7 | Slc1a3 | Glutamate transporter GLAST | 122 | 3/18 | 154 | 8/18 | ||
8 | Gria1 | Glutamate receptor, ionotropic | 57 | 0/9 | 55 | 0/9 | ||
9 | Atp6v1b1 | H+ ATPase | 58 | 0/3 | 26 | 0/3 | ||
10 | Tecta | Tectorin, alpha | 62 | 0/3 | 52 | 0/3 | ||
11 | Tectb | Tectorin, beta | 90 | 0/3 | 01 | 0/3 | ||
12 | Otog | Otogelin | 230 | 0/3 | 63 | 0/3 | ||
13 | Otof | Otoferlin | 231 | 0/3 | 214 | 0/3 | ||
14 | Otop1 | Otopetrin 1 | 54 | 0/3 | 62 | 1/3 | ||
15 | Otop2 | Otopetrin 2 | 247 | 0/3 | 203 | 0/3 | ||
16 | Otop3 | Otopetrin 3 | 60 | 0/3 | 47 | 0/3 | ||
17 | Otos | Otospiralin | 636 | 3/3 | 2,368 | 3/3 | 3.73 | up |
18 | Slc4a7 | Na+/HCO3 - cotransporter | 398 | 3/3 | 444 | 3/3 | 1.11 | |
19 | Kcnj16 | K+ channel | 280 | 2/6 | 239 | 1/6 |
Genes that are expected to be expressed in the organ of Corti, the modiolus or the vestibular labyrinth but not in stria vascularis (1–16), and genes that are expected to be expressed in spiral ligament but not in stria vascularis (17–19) are listed. For parameters 'P', 'Fold' and 'Direction', see the Gene array section in Methods. Fold changes are given when a gene was called Present (P) in Slc26a4+/- or Slc26a4-/- samples in at least half of the available probes. The direction of the fold change is only given when it exceeded 1.30. Fold changes lower than 1.30 were not considered significant.