Table 2.
Characteristics of studies on pharmacological/herbal interventions included in review
| Trial | Population | Interventions | Definitions of impaired glucose tolerance and type 2 diabetes |
|---|---|---|---|
| EDIT, UK (2003)w3 | n=631, some with impaired glucose tolerance, 49% men, 94% white | Factorial trial. Subjects randomised to acarbose (50 mg three time/day) or placebo and metformin (500 mg three times/day) or placebo | WHO 1985 criteria |
| Eriksson, Finland (2006)w38 | n=34 with impaired glucose tolerance and first degree relative with type 2 diabetes. Age 35-70, BMI 25-35, 74% women | Randomised to placebo or 2.5 mg glipizide daily | WHO criteria in 2006 |
| Fan, China (2004)w20 | n=51 with impaired glucose tolerance, age >35, BMI >19 | All received standard diet and exercise advice. Intervention group additionally took jiangtang bushen recipe 2-3 times/week | WHO 1999 criteria |
| Heymsfield, USA and Europe (2000)w28 | n=675 obese adults (120 with impaired glucose tolerance), BMI 30-43 | All recommended low energy diet then randomised to placebo or 120 mg orlistat, three times/day | WHO 1985 criteria |
| Li, China (1999)w30 | n=90 with impaired glucose tolerance, aged 30-60 | 250 mg metformin or placebo three times/day for 12 months | WHO 1985 criteria |
| Pan, China (2003)49 | n=261 with impaired glucose tolerance, aged 35-70, BMI >19 and ≤34, 60% women | 50 mg acarbose or placebo three times/day | American Diabetes Association (ADA) 1997 criteria |
| STOP-NIDDM, Canada, Germany, Austria, Norway, Denmark, Sweden, Finland, Israel and Spain (2002)w33 | n=1429, with impaired glucose tolerance, age 40-70, BMI 25-40 | 100 mg acarbose or placebo three times/day | WHO 1985 criteria |
| TRIPOD, USA (2002)w34 | n=266 insulin resistant (167 with impaired glucose tolerance), Hispanic women with previous gestational diabetes | 400 mg troglitazone or placebo once a day, all received standard diet and exercise | Impaired glucose tolerance diagnosed if sum of 5 OGTT ≥34.7mmol/l. Diabetes defined by ADA 1997 criteria |
| XENDOS, Sweden (2004)w33 | n=3277; 694 had impaired glucose tolerance, age 30-60, minimum BMI 30 | 120 mg orlistat or placebo three times/day, all patients prescribed low calorie diet and exercise | WHO 1994 |
BMI=body mass index; OGTT=oral glucose tolerance test.