Table 1.
Targets, facilitating kinases and consequences of Pin1-mediated transcriptional control
| Client | Motif | Kinase | Consequence | References |
|---|---|---|---|---|
| cJun | S63-P, S73-P | JNK/SAPKs | Transactivation | Wulf et al, 2001 |
| cFos | T232-P, T325-P,T331-P, S374-P | ERKs | Transactivation | Monje et al, 2005 |
| RARα | S77-P | Cdk7 | Transactivation, degradation | Brodani et al, 2005 |
| SRC-3/AIB1 | ND | ND | Transactivation, degradation | Yi et al, 2005 |
| c-Myc | S58-P, S62-P | ERKs | Dephosphorylation by PP2A, degradation | Yeh et al, 2004 |
| β-catenin | S246-P | ND | Stabilization, nuclear localization | Ryo et al, 2001 |
| p53 | S33-P, T81-P, S315-P, S46-P | p38mapk, Cdc2, JNK/SAPKs | Stabilization, transactivation | Zacchi et al, 2002; Zheng et al, 2002; Wulf et al, 2002 |
| p73 | S412-P, T442-P, T482-P | p38mapk | Stabilization, transactivation | Mantovani et al, 2004 |
| p65/Rel | T254-P | ND | Stabilization, transactivation | Ryo et al, 2003 |
| IRF3 | S339-P | ND | Degradation | Saitoh et al, 2006 |
| Rpb1 | S2-P, S5-P, Cdc2/cyclin B | Cdk7, Cdk9 | Dephosphorylation by Fcp1 | Xu et al, 2003; Wilcox et al, 2004 |
Cdc2, cell division cycle 2; Cdk, cyclin-dependent kinase; ERK, extracellular signal-regulated kinase; Fcp1, TFIIF-associating CTD phosphatase-1; GSK-3β, glycogen synthase kinase-3β; IRF3, interferon-regulatory factor 3; JNK, Jun amino-terminal kinase; ND, not yet determined; PP2A, protein phosphatase 2A; RARα, retinoic-acid receptor α; SAPKs, stress-activated protein kinases; SRC-3, steroid-receptor coactivator-3.