Table 3.
Parameters of rectification in mutant Kir2.1 channels at 300 μM spermine
| Z0 | V01/2 | Z1 | V11/2 | Z2 | V21/2 | n | |
|---|---|---|---|---|---|---|---|
| E224G | 2.2 ± 0.2§ | −16.3 ± 0.8§ | n.d. | n.d. | 2.9 ± 0.6 | 88.0 ± 3.0 | 4 |
| E299S | 3.5 ± 0.1§ | −24.9 ± 0.1§ | n.d. | n.d. | 1.9 ± 0.2 | 90.3 ± 0.4 | 2 |
| F254A | 4.2 ± 0.1 | −23.2 ± 0.2 | n.d. | n.d. | n.d. | n.d. | 3 |
| S256I | 4.8 ± 0.3 | −24.2 ± 1.2 | 1.4 ± 0.1 | −54.5 ± 7.1 | n.d. | n.d. | 3 |
| S256K | 5.1 ± 0.2 | −23.1 ± 0.3 | 1.6 ± 0.1 | −45.2 ± 1.8 | n.d. | n.d. | 4 |
§
;The effective valencies and V01/2 may be underestimated due to slow blocking kinetics by spermine. n.d., not determined, i.e. the fitting protocol did not include the specific parameter.