Figure 3. Concentration–response curves in mesenteric arteries to acetylcholine in female (A) and male (B) rats at 3 months of age and female (C) and male (D) rats at 6 months fed either a high or low isoflavone diet.

At 6 months male and female rats fed the high isoflavone diet demonstrated an increased sensitivity to acetylcholine compared with low isoflavone fed rats (*P < 0.05 high isoflavone versus low isoflavone fed rats). Data are presented as the mean ±s.e.m. Relaxation was calculated as percentage noradrenaline (NA)-induced tension.