Table 3.

Contractile and dilator function of mesenteric arteries from male and female high and low isoflavone fed rats

		3 month				6 month
		High isoflavone diet		Low isoflavone diet		High isoflavone diet		Low isoflavone diet
		Female	Male	Female	Male	Female	Male	Female	Male
ACh	pEC50 (−log10m)	7.12 ± 0.17	6.93 ± 0.15	6.78 ± 0.56	6.72 ± 0.36	7.24 ± 0.08	7.34 ± 0.14	6.81 ± 0.16*	6.73 ± 0.17†
	Max (%)	89.01 ± 6.83	97.87 ± 1.68	87.40 ± 9.46	97.87 ± 10.06	88.91 ± 3.81	83.55 ± 7.45	84.80 ± 7.45	95.34 ± 2.29
NO	pEC50 (−log10m)	6.01 ± 0.08	5.92 ± 0.13	5.98 ± 0.11	5.77 ± 0.71	5.50 ± 0.20	4.91 ± 0.21‡	5.72 ± 0.16	4.97 ± 0.17‡
	Max (%)	96.91 ± 3.09	99.65 ± 0.35	98.44 ± 1.18	96.12 ± 2.17	92.25 ± 3.56	93.17 ± 6.25	93.25 ± 4.26	92.07 ± 3.3
NA	pEC50 (−log10m)	6.24 ± 0.17	6.12 ± 0.12	6.14 ± 0.19	5.99 ± 0.04	5.74 ± 0.14	6.14 ± 0.15‡	5.90 ± 0.12	6.06 ± 0.12‡
	Max (mN)	2.69 ± 0.24	3.44 ± 0.36	2.65 ± 0.21	3.02 ± 0.22	3.17 ± 0.24	4.04 ± 0.18 ‡	2.90 ± 0.28	3.70 ± 0.25 ‡
ET-1	pEC50 (−log10m)	7.33 ± 0.04	7.24 ± 0.07	7.20 ± 0.12	7.21 ± 0.02	7.11 ± 0.12	7.30 ± 0.12‡	7.26 ± 0.18	7.27 ± 0.07‡
	Max (mN)	3.33 ± 0.36	3.68 ± 0.31	3.74 ± 0.21	3.77 ± 0.17	3.24 ± 0.31	3.38 ± 0.14	3.38 ± 0.14	3.92 ± 0.25

Data are presented as the mean ±s.e.m. of 6–10 animals per group.

^*P < 0.05 low isoflavone females compared with high isoflavone females, ANOVA.

^†P < 0.05 low isoflavone males compared with high isoflavone males.

^‡P < 0.05 males (both groups) compared with females (both groups), ANOVA.