Table 4.
Contractile and dilator function of aortas from male and female high and low isoflavone fed rats
| 3 month | 6 month | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| High isoflavone diet | Low isoflavone diet | High isoflavone diet | Low isoflavone diet | ||||||
| Female | Male | Female | Male | Female | Male | Female | Male | ||
| ACh | pEC50 (−log10m) | 6.08 ± 0.14 | 6.08 ± 0.14 | 6.23 ± 0.09 | 6.31 ± 0.11 | 6.52 ± 0.16 | 6.38 ± 0.10 | 6.63 ± 0.09 | 6.36 ± 0.12 |
| Max (%) | 80.56 ± 0.14 | 83.09 ± 0.14 | 84.28 ± 0.09 | 80.73 ± 0.11 | 85.52 ± 3.43 | 80.74 ± 2.22 | 87.45 ± 2.22 | 75.37 ± 7.58 | |
| NO | pEC50 (−log10m) | 5.56 ± 0.20 | 4.98 ± 0.132 | 5.54 ± 0.21 | 5.18 ± 0.08 | 5.25 ± 0.08 | 4.95 ± 0.11 | 5.10 ± 0.26 | 5.07 ± 0.08 |
| Max (%) | 99.50 ± 1.54 | 98.90 ± 0.78 | 95.72 ± 3.29 | 99.22 ± 0.61 | 96.32 ± 3.45 | 97.68 ± 0.96 | 97.48 ± 1.60 | 99.17 ± 0.3 | |
| PE | pEC50 (−log10m) | 5.67 ± 0.27 | 5.67 ± 0.242 | 5.57 ± 0.24 | 5.49 ± 0.26 | 5.81 ± 0.05 | 5.74 ± 0.08 | 5.71 ± 0.11 | 5.8 ± 0.12 |
| Max (% K+) | 118.24 ± 13.43 | 121.44 ± 13.43 | 106.16 ± 6.54 | 121.44 ± 4.52 | 107.38 ± 13.28 | 105.57 ± 7.64 | 103.44 ± 12.26 | 119.09 ± 7.8 | |
| Stretch | Max (mN) | 20.92 ± 1.42 | 18.78 ± 0.95 | 19.53 ± 0.93 | 21.21 ± 1.47 | 16.91 ± 0.66 | 18.45 ± 0.84 | 18.55 ± 1.11 | 18.21 ± 0.86 |
Maximum relaxation (Max (%)) to acetylcholine and nitric oxide is presented as percentage phenylephrine-induced contraction. Maximum constriction to phenylephrine is presented as percentage high potassium (K+)-induced contraction (Max (%K+)). Data are presented as the mean ±s.e.m. of 6–10 animals per group.