Table 1.

Non-Malignant Disorders Treated With Cord Blood

Disorder	Number Treated	Outcome	Ref.
Hurler's syndrome	20	17 of the 20 children were alive a median of 905 days after transplantation, with complete donor chimerism and normal peripheral-blood alpha-L-iduronidase activity	[100]
Duchenne muscular dystrophy	1	On 42nd day, physical examination revealed obviously improvement in walking, turning the body over, and standing up	[101]
Malignant infantile osteopetrosis	1	Normalization of spine bone mineral density.	[102]
Rothmund-Thomson syndrome	1	Complete immune reconstitution	[55]
Buerger's disease	4	Ischemic rest pain suddenly disappeared. Digital capillaries were increased in number and size.	[84]
Spinal Cord Injury	1	Improved sensory perception and movement in the SPI patient's hips and thighs within 41 days of cell transplantation. Regeneration of the spinal cord at the injured site	[85]
Krabbe's disease	25	Progressive central myelination and continued gains in developmental skills, and most had age-appropriate cognitive function and receptive language skills in patient subset	[14]
Omenn syndrome	1	T cell reconstitution	[103]
Non-healing wounds	2	Accelerated healing	[86]
Refractory anemia	3	All patients are alive and free of disease at between 17 and 39 months after cord blood administration	[104]
Diamond-Blackfan anemia	1	Successful seroconversion to vaccines (diphtheria, pertussis, tetanus, rubella, measles, and BCG) administered 22–34 months post-transplant.	[105]
Severe chronic active Epstein-Barr virus	1	Complete remission without circulating EBV-DNA has continued for 15 months transplant.	[106]
Behcet's disease	1	Twenty-three months after CBT, the patient is doing well and has no signs or symptoms of Behcet's disease	[9]
Mucopolysaccharidosis type IIB (Hunter syndrome)	1	Two years after transplant approximately 55% normal plasma iduronate sulfatase. activity has been restored and abnormal urinary excretion of glycosaminoglycans has nearly completely resolved.	[107]