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Effect of anti-ICAM-1 mAb on leukostasis and vascular leakage in diabetic retina. When ICAM-1 bioactivity was inhibited via systemic administration of the ICAM-1 neutralizing antibody, retinal leukostasis (A) and albumin permeation (B) were decreased 48.5% (5 mg/kg; n = 5; P < 0.001) and 85.6% (5 mg/kg; n = 4; P < 0.0001), respectively. NS = not significant.
