Table 1.
Characteristics of control, diabetic, mouse IgG1-treated diabetic, and anti-ICAM-1 mAb-treated diabetic rats
Characteristic | Control | Diabetes | Diabetes + 5 mg/kg mouse IgG1 | Diabetes + anti-ICAM-1 mAb
|
|
---|---|---|---|---|---|
3 mg/kg | 5 mg/kg | ||||
Number | 6 | 7 | 5 | 5 | 5 |
Body weight, g | 271 ± 12 | 240 ± 12* | 235 ± 9* | 238 ± 6* | 239 ± 12* |
Plasma glucose, mg/dl | 123 ± 19 | 332 ± 35* | 316 ± 61* | 351 ± 83* | 373 ± 68* |
Blood pressure, mmHg | 111 ± 6 | 104 ± 12 | 109 ± 14 | 105 ± 9 | 105 ± 10 |
Leukocyte count, ×103/μl | 6.1 ± 1.6 | 5.0 ± 1.5† | 5.3 ± 0.8† | 6.9 ± 1.4 | 7.4 ± 2.3 |
Values are means ± SD; 1 mmHg = 133 Pa.
P < 0.0001 vs. control rats;
P < 0.05 vs. 5 mg/kg anti-ICAM-1 mAb-treated diabetic rats.