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. 2007 Feb 13;4(2):e59. doi: 10.1371/journal.pmed.0040059

Figure 2. Challenge of huN1-Immunized Mice with Influenza Viruses Possessing Homologous or Heterologous NA Genes.

Figure 2

Mice immunized twice with huN1 DNA or saline alone (control) were inoculated intranasally with PR8-huN1 (A), PR8-avN1 (B), or A/Vietnam/1203/04 (C). Mean weight change and survival data are shown. Differences in survival between huN1 DNA-vaccinated and saline control groups were statistically significant for PR8-huN1 challenge (p < 0.001) and A/Vietnam/1203/04 challenge (p = 0.016), and approached but did not reach significance for PR8-avN1 challenge (p = 0.055). Error bars represent standard deviation values. Statistical comparisons are by Fisher's exact test.