Table 1.
Fatty acids measured from E19 skin samples. Significant changes using linear regression on combined Elovl4 270x and knockout are in bold. Heterozygous and Homozygous represent combined values of both Elovl4 270x and knockout mice. (* decreasing and # increasing compared to wild-type)
| Elovl4+/+ | Elovl4+/270x | Elovl4270x/270x | Elovl4+/- | Elovl4-/- | Heterozygous | Homozygous | |
|---|---|---|---|---|---|---|---|
| C8:0 - Octanoic | 0.1326% | 0.4273% | 0.3018% | 0.0042% | 0.0044% | 0.2157% | 0.1531% |
| C9:0 - Nonanoic | 0.7218% | 2.4780% | 1.9750% | 0.0134% | 0.0175% | 1.2457% | 0.9963% |
| C10:0 - Capric | 0.2219% | 0.7687% | 0.6058% | 0.0033% | 0.0044% | 0.3860% | 0.3051% |
| C11:0 - Undecanoic | 0.0596% | 0.1698% | 0.1671% | 0.0051% | 0.0085% | 0.0875% | 0.0878% |
| C12:0 - Lauric | 0.5006% | 1.5230% | 1.3846% | 0.0533% | 0.0847% | 0.7881% | 0.7347% |
| C13:0 - Tridecanoic | 0.0552% | 0.1247% | 0.1050% | 0.0214% | 0.0268% | 0.0731% | 0.0659% |
| C14:0 - Myristic | 1.2141% | 1.2878% | 1.1034% | 1.1025% | 1.0868% | 1.1952% | 1.0951% |
| C15:0 - Pentadecanoic | 0.4841% | 0.4167% | 0.4651% | 0.4655% | 0.4073% | 0.4411% | 0.4362% |
| C16:0 - Palmitic | 19.8759% | 17.3620% | 14.4374% | 22.6083% | 21.9211% | 19.9851% | 18.1792% |
| C17:0 - Heptadecanoic | 0.4221% | 0.3611% | 0.3879% | 0.4419% | 0.4203% | 0.4015% | 0.4041% |
| C18:0 - Stearic | 10.9095% | 11.9813% | 10.3545% | 10.3991% | 9.1910% | 11.1902% | 9.7728% |
| C20:0 - Arachidic | 0.4324% | 0.4672% | 0.4800% | 0.3888% | 0.3732% | 0.4280% | 0.4266% |
| C21:0 - Heneicosanoic* | 0.0677% | 0.0584% | 0.0600% | 0.0598% | 0.0481% | 0.0591% | 0.0540% |
| C22:0 - Behenic | 1.3721% | 1.1230% | 1.2751% | 1.3003% | 1.1393% | 1.2116% | 1.2072% |
| C23:0 - Tricosanoic | 0.4071% | 0.2416% | 0.3257% | 0.4066% | 0.3112% | 0.3241% | 0.3185% |
| C24:0 - Lignoceric | 6.8596% | 4.6244% | 7.6147% | 7.2884% | 6.9943% | 5.9564% | 7.3045% |
| C25:0 - Pentacosanoic | 0.9133% | 0.4115% | 0.7714% | 1.2422% | 1.1816% | 0.8268% | 0.9765% |
| C26:0 - Hexacosanoic# | 3.1668% | 1.8104% | 4.1685% | 4.1543% | 4.8060% | 2.9823% | 4.4873% |
| C28:0 - Octacosanoic* | 0.1820% | 0.0903% | 0.0557% | 0.1929% | 0.0704% | 0.1416% | 0.0630% |
| C29:0 - Nonacosanoic* | 0.0180% | 0.0106% | 0.0086% | 0.0194% | 0.0055% | 0.0150% | 0.0070% |
| C30:0 - Triacontanoic* | 0.0754% | 0.0292% | 0.0000% | 0.0655% | 0.0105% | 0.0473% | 0.0052% |
| C10:1 - Caproleic | 0.0018% | 0.0106% | 0.0043% | 0.0000% | 0.0000% | 0.0053% | 0.0021% |
| C11:1 - Undecaenoic | 0.0694% | 0.2124% | 0.1801% | 0.0061% | 0.0075% | 0.1093% | 0.0938% |
| C12:1 - Dodecaenoic | 0.0059% | 0.0080% | 0.0129% | 0.0013% | 0.0028% | 0.0046% | 0.0078% |
| C13:1 - Tridecaenoic | 0.0027% | 0.0080% | 0.0086% | 0.0000% | 0.0000% | 0.0040% | 0.0043% |
| C15:1 - Pentadecaenoic | 0.0084% | 0.0292% | 0.0214% | 0.0010% | 0.0019% | 0.0151% | 0.0116% |
| C16:1(n-9) | 0.5706% | 0.5762% | 0.4370% | 0.5887% | 0.5609% | 0.5824% | 0.4989% |
| C17:1 - Heptadecaenoic | 0.5139% | 0.1779% | 0.2507% | 0.2972% | 0.7126% | 0.2376% | 0.4816% |
| C18:1(n-9) - Oleic | 16.0053% | 14.9932% | 15.6582% | 15.7484% | 14.9762% | 15.3708% | 15.3172% |
| C20:1(n-9) - Eicosenoic | 0.1894% | 0.2230% | 0.2400% | 0.1567% | 0.1667% | 0.1898% | 0.2034% |