Table 1.

Native sTat, but not oxTat, suppresses antibody response to a coadministered antigen in mice

Group	Immunogen	Exp. 1
		αTat titer		Exp. 2
		Wk 2	Wk 6	αTat titer	αp24 titer
	sTat	<100	922  (822)
	oxTat	12,750  (670)	17,675  (4,925)
I	p24			0	9,109  (1,337)
II	sTat + p24			983  (317)	1,100  (384)
III	oxTat + p24			9,033  (657)	8,013  (1,410)
IV	oxp24			0	7,944  (1,245)

Analysis by ELISA of antibody responses to recombinant native Tat, or to recombinant p24 protein (SF2, Chiron). Titers were determined by linear regression analysis of serial 1:100, 1:1,000, and 1:10,000 dilutions. Results are the mean (SD). Statistical analysis (P) was performed by two-tailed Student’s t test (two-way), or by ANOVA (four-way). In Exp. 1, P < 0.07; in Exp. 2, P < 0.0004 (II vs. III, αTat titer) and P < 0.0047 (α p24 titer).