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Agreement among methods for measuring HER2
| Method | Cohen's kappa | Sensitivity | Specificity |
| FISH versus CB11 | 83.0% (SE 5.3%) | 97% | 93% |
| HercepTest versus FISH | |||
| (0–1 versus 2–3) versus FISH | 72.0% (SE 6.2%) | 92% | 87% |
| (0–2 versus 3) versus FISH | 79.2% (SE 6.0%) | 78% | 97% |
| HercepTest versus CB11 | |||
| (0–1 versus 2–3) versus CB11 | 70.0% (SE 6.3%) | 100% | 85% |
| (0–2 versus 3) versus CB11 | 84.2% (SE 5.4%) | 90% | 96% |
FISH, fluorescent in situ hybridization; SE, standard error for Cohen's kappa.
