Table 1.

Genes with significant association with warfarin dose, based on univariate regression of square root of dose

Gene	SNP	MAF	n	Univariate R2	P-Value	r2 with best SNP
VKORC1	rs9923231	0.391	181	0.317	1.91 × 10−15**	–
	rs2359612	0.389	200	0.290	2.30 × 10−15**	0.968
	rs9934438	0.383	169	0.292	3.59 × 10−13**	1.000
	rs7294	0.384	188	0.208	4.14 × 10−10**	0.385
	rs4889490	0.446	199	0.160	3.821 × 10−8**	0.461
	rs4889537	0.372	199	0.142	3.158 × 10−7**	0.209
	rs4889599	0.366	194	0.124	3.270 × 10−6**	0.305
	rs8046978	0.214	197	0.047	0.00906	0.173
	rs11642603	0.093	192	0.027	0.02304	0.070
	rs11642466	0.103	195	0.025	0.02623	0.080
	rs7194347	0.343	197	0.032	0.04069	0.153
CYP2C9	rs1057910 (*3)	0.058	201	0.141	2.784 × 10−7**	–
	rs9332108	0.064	201	0.141	2.784 × 10−7**	0.890
	rs9325473	0.055	189	0.147	3.753 × 10−7**	0.908
	rs1057911	0.067	191	0.145	4.218 × 10−7**	0.890
	rs9332214	0.059	198	0.139	4.654 × 10−7**	0.878
	rs4917639	0.173	197	0.118	4.944 × 10−6**	0.276
	rs2860905	0.214	193	0.072	0.00080*	0.224
CYP2C19	rs3814637	0.059	195	0.106	0.00002**	0.838a
	rs17882687(*15)	0.08	183	0.044	0.00417*	0.395a
CYP2C18	rs7896133	0.056	193	0.074	0.00013**	0.869a
PROC	rs2069919	0.372	182	0.090	0.00022*	–
	rs1799809	0.433	188	0.078	0.00055*	0.777
	rs2069901	0.441	177	0.072	0.00147*	0.785
	rs2069910	0.387	178	0.046	0.01678	0.414
APOE	rs429358 + rs7412b	0.251	201	0.051	0.00570*	–
EPHX1	rs4653436	0.266	196	0.048	0.00848	–
CALU	rs11653	0.366	197	0.047	0.00944	–
	rs1006023	0.331	200	0.033	0.03789	0.865
	rs2307040	0.336	200	0.033	0.03811	0.867
	rs339054	0.461	195	0.032	0.04487	0.612
GGCX	rs12714145	0.408	198	0.034	0.03320	–
ORM1-2	rs1687390	0.062	149	0.026	0.04964	–

The SNPs are listed with the lowest P-value first. The LD (r²) between the SNP with the lowest P-value and others in the gene or gene cluster is shown. n is the number of successfully genotyped individuals

^aLinkage disequilibrium with CYP2C9*3 (rs10579103)

^bNote that the two APOE SNPs are not significant individually, only when assessed as E2 + E4 vs. E3

*The test is significant, based on correction for the effective number of tests in each gene or gene cluster

**Corresponds to experiment-wise significance, based on ∼285 independent effective tests (P < 1.75 × 10⁻⁴)