Table 3.
Significant (P < 0.05) regression results for SNPs in the CYPC2 gene cluster
| Gene | SNP | R2 with *2 model | P-Value | R2 with *3 model | P-Value |
|---|---|---|---|---|---|
| CYP2C8 | rs11572080 | 0.001 | 0.502 | 0.017 | 0.005 |
| CYP2C9 | rs9332108 | 0.109 | 1.57 × 10−10 | 0.000 | 0.999 |
| CYP2C9 | rs1057910 (*3) | 0.109 | 1.57 × 10−10 | – | – |
| CYP2C9 | rs1057911 | 0.114 | 2.97 × 10−10 | 0.000 | 0.999 |
| CYP2C9 | rs9325473 | 0.112 | 5.45 × 10−10 | 0.000 | 0.999 |
| CYP2C9 | rs4917639 | 0.100 | 1.33 × 10−9 | 0.025 | 3.56 × 10−3 |
| CYP2C9 | rs9332214 | 0.098 | 1.50 × 10−9 | 0.000 | 0.999 |
| CYP2C9 | rs2860905 | 0.048 | 1.86 × 10−4 | 0.009 | 0.153 |
| CYP2C9 | rs4917636 | 0.004 | 0.213 | 0.026 | 3.63 × 10−3 |
| CYP2C9 | rs4607998 | 0.004 | 0.252 | 0.026 | 2.85 × 10−3 |
| CYP2C9 | rs1799853 (*2) | – | – | 0.024 | 4.00 × 10−3 |
| CYP2C9 | rs1934966 | 0.000 | 0.999 | 0.015 | 8.72 × 10−3 |
| CYP2C9 | rs9332222 | 0.000 | 0.999 | 0.025 | 3.86 × 10−3 |
| CYP2C18 | rs7896133 | 0.063 | 5.17 × 10−7 | 0.000 | 0.999 |
| CYP2C18 | rs2901783 | 0.020 | 0.029 | 0.004 | 0.471 |
| CYP2C19 | rs3814637 | 0.098 | 3.76 × 10−9 | 0.000 | 0.896 |
| CYP2C19 | rs17882687 | 0.047 | 5.19 × 10−5 | 0.000 | 0.828 |
Additional dose variance (R2) explained by each SNP and the corresponding P-value is shown for two multiple regression models of warfarin dose. Both models contain VKORC1 SNP rs2359612 and non-genetic predictors identified by Wadelius et al. (2005). CYP2C9*2 is included in the first alternative regression model and CYP2C9*3 is included in the second model. A non-significant P-value for the *2 model but highly significant result for the *3 model implies that *2 fully accounts for the tested SNP’s contribution to dose variance (and vice versa). Thus, *2 or *3 fully account for each tested SNP apart from rs4917639
SNPs giving non-significant (P > 0.05) results in both models are: CYP2C8 (rs2275622, rs7898759, rs1557044, rs2275620, rs1341163, rs1891071, rs1058932, rs1058930, rs947173, rs17110453, rs3752988); CYP2C9 (rs9332197, rs2475376, rs1856908, rs1934964, rs2153628, rs10509679, rs2298037); CYP2C18 (rs10736086, rs10509675, rs12249418, rs7099637, rs7898763, rs7919273, rs1926706, rs2281891, rs1926711, rs7478002, rs2860837, rs2860840); CYP2C19 (rs4244284, rs12248560, rs3758580, rs4250786, rs17879456, rs17882419, rs4417205, rs1853205)