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. Author manuscript; available in PMC: 2007 Feb 13.
Published in final edited form as: Int Immunopharmacol. 2006 Nov 28;7(2):249–265. doi: 10.1016/j.intimp.2006.10.012

Fig. 2.

Fig. 2

Anti-CD4 mAb alone induce equivalent OVA unresponsiveness as the anti-CD4/anti-CD8 mAb cocktail. BALB/c mice were treated with 2.5 × 106 CD4+ KJ1-26+ cells isolated from BALB/c DO11.10 mice and either OVA and anti-CD4 plus rat IgG2a isotype control (Group 1), or OVA and the anti-CD4/anti-CD8 mAb cocktail (Group 2), or with OVA alone (Group 3). Twenty one days later all mice were bled and OVA-specific antibody measured (panel a). Six weeks after OVA and mAb treatment all mice were boosted with OVA and 10 days later OVA-specific antibody was measured in the serum by ELISA (panel b). Data shown are mean ± SEM and are representative of 3 experiments. ** indicates statistical significance to 0.001–0.009. The Mann–Whitney test was used to determine statistical significance. n = 6 per group.