Figure 7.

Synthetic compounds 1–4 produced smaller changes in intracellular Ca²⁺ compared to poly-APS. A) Bar chart showing mean percentage changes in fluorescence compared to baseline values. Samples 1, 2 and 3 produced modest changes in intracellular Ca²⁺ that were significantly smaller than those seen with poly-APS (*P < 0.05, **P < 0.01 & ***P < 0.001). Sample 4 at a concentration of 5 μg/ml gave a similar response to 0.5 μg/ml poly-APS. B) Example traces of mean responses to the synthetic compounds and poly-APS. Each trace is comprised of the mean from 17–34 neurones.