Table 2.
Patient ID | Histology of core | Bilateral | KIT protein expression | KIT mutation in codon 816, exon 17 |
PT-09 | DG (w/GB) | - | GAC to TAC, Asp to Tyr | |
PT-16 | DG | + | GAC to TAC, Asp to Tyr | |
PT-49 | DG | ++ | GAC to CAC, Asp to His | |
PT-52 | DG | ++ | GAC to GTC, Asp to Val | |
PT-58 | DG | - | GAC to GTC, Asp to Val | |
PT-04 | DG | Bilateral | ++ | wt |
GB | Bilateral | ++ | wt | |
PT-32 | DG | Bilateral | ++ | wt |
YST | Bilateral | - | wt | |
PT-35 | DG (left ovary) | Bilateral | ++ | wt |
DG (right ovary) | Bilateral | ++ | wt | |
PT-57 | GB | Bilateral | M | wt |
DG (left ovary) | Bilateral | ++ | wt | |
DG (right ovary) | Bilateral | ++ | wt | |
PT-03 | DG (w/GB) | ++ | wt | |
EC | - | wt | ||
GB | - | wt | ||
PT-15 | DG | M | wt | |
PT-19 | DG | - | wt | |
PT-27, 39 | DG | ++ | wt | |
PT-40 | DG (w/GB) | ++ | wt | |
PT-48 | DG | + | wt | |
PT-53 | CC | - | wt | |
DG | + | wt | ||
PT-28 | DG | ++ | wt | |
YST | - | wt | ||
PT-08 | YST | M | wt | |
PT-20 | YST | + | wt | |
PT-25,33,43,45,54,55 | YST | - | wt | |
PT-06,10,18,23,31,34,44,46,47,51 | IT | - | wt | |
PT-12, 22 | IT | M | wt | |
PT-36, 37 | YST, IT | - | wt | |
PT-11, 59, 56 | SCC | - | wt |
Staining intensity = '++': >50%, of tumour cells stained; '+': staining in approximately 20–50% of tumour cells; '+-': few cells stained; '-': no positive cells detected. Abbreviations: DG = dysgerminoma; GB = gonadoblastoma; YST = yolk sac tumour; EC = embryonal carcinoma; CC = choriocarcinoma; IT = immature teratoma; OGCT = ovarian germ cell tumour; PT = patient; SCC = small cell carcinoma; M = missing; wt = wild type.