Table 3.
Overview of the sample content of the Ovarian Germ Cell tumour – Tissue Microarray
| Diagnosis of tumour(s) | No. CORES | No. PATIENTS | Histology of analysed component(s) | |
| Pure DG | - Unilateral - Bilateral |
10 3 |
10 2 |
DG 1 case one side; 1 case both sides |
| DG/GB | - Unilateral - Bilateral |
3 6 |
3 3 |
2 cases DG and GB; 1case only DG |
| Pure YST | - Unilateral | 7 | 7 | YST |
| Pure IT | - Unilateral | 15 | 15 | IT |
| Mixed OGCT: DG/YST | - Unilateral - Bilateral |
2 2 |
1 1 |
DG and YST DG and YST |
| Mixed OGCT: YST/EC | - Unilateral | 1 | 1 | YST |
| Mixed OGCT: DG/EC/GB | - Unilateral | 3 | 1 | DG, EC, and GB |
| Mixed OGCT: YST/IT | - Unilateral | 6 | 5 | 3 cases only YST; 1 case only IT; 1 case YST and IT |
| Mixed OGCT: DG/CC | - Unilateral | 2 | 1 | DG and CC |
| SCC | - Unilateral | 8 | 8 | SCC |
The tissue microarray (TMA) contained of 60 cores obtained from OGCTs of 50 patients and 8 small cell carcinomas from 8 patients. Six patients exhibited bilateral neoplasia. H&E stained sections from several blocks were re-evaluated by a pathologist (V.M.A.), classified according to the WHO recommendations [1], and the most optimal tissue blocks were chosen. The TMA was constructed by transferring core biopsies of 0.6 μm in diameter from each donor block into an acceptor block (Beecher Instruments, Sun Prairie, USA). Abbreviations: GCT = germ cell tumour; No. = number; DG = dysgerminoma; GB = gonadoblastoma; YST = yolk sac tumour; IT = immature teratoma; EC = embryonal carcinoma; CC = choriocarcinoma; SCC = small cell carcinoma.