TABLE 1.

Comparison of immunization “take” rates after LAIV or TIV immunization measured by ASC, neutralization assay, and HAI response

Assay antigen	Assay	% with significant increase over baselined
		Adults		5- to 9-yr-old children
		LAIV	TIV	LAIV	TIV
TIVa	Effector IgA ASC	47.4 §	52.4	28.6 §	52.6 #,§
TIV	Effector IgG ASC	79.0 #,§	81.0	86.7	100.0
One of three strainsb	Neutralizing Abse	26.3 †,‡	66.7 ‡	66.7 †	94.7
One of four strainsc	HAI	15.8 †,‡	61.9 ‡	78.6	94.7
A/Wyoming H3N2	Neutralizing Abs	21.1 †	52.2	37.5 †	78.9
A/Wyoming H3N2	HAI	15.8 †	43.5 ‡	26.7 †	78.9

^aInfluenza virus-specific ASC were assayed against TIV vaccine containing A/Wyoming, A/New Caledonia, B/Jiangsu, and B/Hong Kong as the immobilized antigen.

^bSignificant increase in neutralizing antibody titer was detected against at least one virus strain of three strains tested: A/Wyoming, A/New Caledonia, and B/Shanghai.

^cA significant increase in HAI titer was detected against at least one virus strain of four strains tested: A/Wyoming, A/New Caledonia, B/Shanghai, and B/Jilin.

^d†, P < 0.05, percentage of antibody responders after LAIV was significantly lower than after TIV vaccination; ‡, P < 0.05, percentage of antibody responders among adults was significantly lower than in children after TIV or LAIV vaccination; # and §, P < 0.05, percentages of flu-specific IgA and IgG ASC responders were significantly higher or lower than the percent neutralizing antibody responders against one of three strains of influenza virus (#) or among HAI responders against one of four strains of influenza virus (§).

^eNeutralizing Abs, neutralizing antibodies.