FIG. 4.
Immune responses detected post-SHIVmn229 challenge. (A to D) Time courses of the mean (± SE of the mean) CD4 T-cell (left panel) and CD8 T-cell (right panel) immune responses postchallenge are shown for each vaccine group by IFN-γ ICS to stimulation with SIV Gag 15-mer peptide pool (A), SIV Pol 15-mer peptides (B), HIV-1 subtype AE Env 15-mer peptide pool (C), or a combined pool of HIV-1 subtype AE Tat and Rev 15-mer peptide pools (D). (E) CD8 T-cell responses to the SIV Gag epitope KP9 were measured in the subset of macaques that were Mane-A*10+ by MHC tetramer. (F) Some monkeys mounted responses to other known pigtail macaque Gag epitopes (KW9, CM8, AF9, and GL8) prechallenge, and these were followed postchallenge by IFN-γ ICS.