FIG. 6.
Comparison of the immunogenicity and efficacy of subtype B (black circles) and subtype AE (gray squares) SHIV vaccination of groups of six pigtail macaques. Two vaccine regimens, DNA/FPV-low-dose FPV (left panel) and DNA only (right panel), were identical between the B and AE subtype SHIV vaccinations, and both were challenged intrarectally with the same dose, route, and stock of SHIVmn229. (A) Vaccine-induced SIV Gag-specific CD8 T-cell responses by IFN-γ ICS. (B) Plasma SHIV RNA by real-time PCR after challenge. (C) Peripheral CD4 T cells after challenge. (D) Postchallenge SIV Gag-specific CD8 T-cell responses by IFN-γ ICS.