TABLE 3.
Activation or inhibition of quorum sensing by peptide analogs
| Peptide | AC50 (nM)a | IC50 (nM)b |
|---|---|---|
| UA159sp | 25 | NAc |
| TPC1 | 29 | NA |
| TPC2 | 132 | NA |
| TPC3 | NA | 368 |
| TPC4 | NA | 292 |
| TPN1 | 29 | NA |
| TPN2 | 33 | NA |
| TPN3 | 35 | NA |
| TPN4 | 143 | NA |
| F7Q | 322 | 10,300 |
| F11Q | 328 | 11,500 |
| F15Q | 334 | 11,800 |
a
The AC50 were calculated from a dose-response curve using GraphPad Prism 4.
b
The IC50 were determined from an antagonist inhibition curve by plotting the data against various log concentrations of an antagonist in the presence of an effective concentration (50 nM) of UA159sp.
c
NA, not assayed.