FIG. 1.

(a) Survival of mice after intranasal infection with 10⁶ CFU TIGR4. The asterisk indicates that the P value is <0.01 for a comparison of the survival times of TIGR4Δrr09 and wild-type strain TIGR4. (b) Bacterial loads in BALF, homogenized lungs, and blood 24 h after intranasal infection with 10⁶ CFU. An asterisk indicates that the P value is <0.01 for a comparison of the bacterial loads recovered from different sites. The bars indicate geometric means, and the error bars indicate standard errors of the means. wt, wild type.