Table 1.

Effect of anti-gelatinase B antibodies on IL-8-induced mobilization of HPC

Time	CFU per ml
	Anti-gelatinase B antibody								Anti-CD5
	0.1 mg/kg (A)		1 mg/kg (B)		1 mg/kg (C)		2 mg/kg (D)		1 mg/kg (E)
	−	+	−	+	−	+	−	+	+
Before IL-8 induction	2	1	5	7	7	6	9	2	6
After IL-8 induction	86	24	195	12	101	72	67	7	115

Animals were first treated with a single bolus injection of 0.1 mg/kg IL-8 (−). Five or six days later, anti-gelatinase B antibodies were administered as a single bolus injection, followed after 2 h by a second bolus injection of 0.1 mg/kg IL-8. The maximal numbers of CFU per ml of blood at 15–30 min are reported for IL-8 alone (−) and after pretreatment with increasing doses of anti-gelatinase B antibodies (+) (animals A–D) or anti-CD5 as control (animal E).