FIG. 12.

Model of ORF9 protein/IE62 interactions. In this model, IE62 is phosphorylated by the ORF66 kinase either in the nucleus or in the cytoplasm late in infection, resulting in its exclusion from the nucleus. IE62 can then interact with the ORF9 protein and potentially, either simultaneously or sequentially, with the ORF47 kinase. This complex then binds to the microtubules via the ORF9 protein. An alternative mechanism could involve initial binding of ORF9 to microtubules, followed by recruitment of the other proteins.