TABLE 1.
Characteristics of R5 and (R5)X4 HIV-1 virus variants
| Patient no. (sexa; seropositivity at entry) | Viruses early post-X4
|
Viruses late post-X4
|
||||
|---|---|---|---|---|---|---|
| Time since SC or entry (mo)b | Time since X4 variant detected (mo) | Coreceptor usage (n) | Time since SC or entry (mo)b | Time since X4 variant detected (mo) | Coreceptor usage (n)c | |
| ACH0039 (M; no) | 11.2 | −4.9 | R5 (1) | 38.9 | 22.8 | R5 (2), X4 (1) |
| 18.2 | 2.1 | R5 (1), R5X4 (2) | 51.2 | 35.0 | R5 (1), X4 (3) | |
| 21.1 | 5.0 | R5 (2), R5X4 (1) | ||||
| ACH0171 (M; no) | 61.0 | −1.5 | R5 (1), R5X4 (1)c | 89.5 | 27.0 | R5 (4), R5X4 (4) |
| 67.0 | 4.5 | R5 (2), R5X4 (2) | ||||
| 73.0 | 10.5 | R5 (1), R5X4 (1) | ||||
| ACH1120 (M; no) | 53.3 | 6.0 | R5 (4), R5X4 (2), X4 (2) | 64.6 | 17.2 | R5 (4) |
| 66.4 | 19.1 | R5X4 (4) | ||||
| ACH6052 (M; yes) | 0d | Unknownd | R5 (3), X4 (5) | 32.0 | Unknownd | R5 (3), X4 (5) |
| ACH9012 (F; no) | NTe | NT | NT | 3.5 | 3.5 | R5 (3), X4 (3) |
a
M, male; F, female.
b
Time since seroconversion (SC) or entry of patient into HIV+ cohort.
c
As determined with transfected U87 indicator cell lines. n, no. of clones. For each time point, the presence of CXCR4-using variants in a bulk virus culture was determined in the MT2 assay, in which CXCR4 usage of single virus isolates can be missed.
d
ACH6052 was seropositive and carried X4 variants at the time of entry into the cohort.
e
NT, not tested.