FIG. 3.
HHV-7 replication in human lymphoid tissues coinfected with R5SF162 or X4LAI.04. Sets of matched tissue blocks (27 blocks for each experimental condition from each donor) were infected with HHV-7 alone or together with one of the HIV-1 variants. HHV-7 replication was evaluated by measuring the number of HHV-7 genome equivalents accumulated in the culture medium. (A) Typical (n = 8) kinetics of HHV-7 replication in singly infected and HIV coinfected tissues. Shown are the means ± the SEM of the accumulation of HHV-7 genomes in culture medium during 3 days between medium changes. (B) Relative replication of HHV-7 in tissues coinfected with R5SF162 and X4LAI.04 Presented are the means ± the SEM of the production of HHV-7 genomes in culture medium over 12 days postinoculation for tissues from eight donors expressed as a percentage of the HHV-7 genome production in matched singly infected tissues. An asterisk denotes a significant difference (P < 5 × 10−2).