TABLE 2.
Autologous neutralization of transmitted variants in B2
| Baby plasma | SHIV-SF162P3 inoculuma | B2w2 pseudovirusb
|
||
|---|---|---|---|---|
| P2 | P8 | P9 | ||
| B2w0 | <50 | 1600 | 158 | |
| B2w2 | >675 | <50 | 800 | <50 |
| B2w4 | >675 | <50 | 620 | <50 |
| B2w6 | <50 | 568 | <50 | |
| B2w24 | >675 | <50 | <50 | <50 |
| M2 plasma at delivery | 200 | <50 | 200 | <50 |
| Total PNG no. in gp160c | 23-24 | 24 | 23 | 24 |
a
50% neutralization titers (50% inhibitory concentrations).
b
Unique, missense mutation-free, full-length envelope sequences (gp160) from babies and paired mothers were cloned, sequenced, and used for pseudovirus production; 50% neutralization titers of these pseudoviruses from mother-infant pairs are reported. B2w2, B2 at 2 weeks postbirth.
c
The average number of PNG sites for full-length gp160 was computed using AminoTrack (Seattle Biomedical Research Institute).