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. 2006 Nov 15;81(3):1479–1491. doi: 10.1128/JVI.01861-06

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Copyright © 2007, American Society for Microbiology

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FIG. 4. — Effect of poly(I:C) on VSV infection. Using an MTT cell viability assay, the effect of poly(I:C) pretreatment in several concentrations was assessed. U-87 glioblastoma cells were effectively killed by virus in the absence or presence of poly(I:C). Note the slightly stronger oncolysis by VSV-rp30a. Noteworthy is that in the presence of poly(I:C), VSV action on U-87 cells was even stronger than in nonpretreated cultures, suggesting a synergistic effect of poly(I:C) with VSV/VSV-rp30a. In contrast, normal human astrocytes were completely protected from VSV infection. hpi, hours postinfection.