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Effect of IFN-α and poly(I:C) on viral replication. Viral replication was assessed using plaque assays. U-87 glioblastoma cultures and normal human astrocytes were infected at an MOI of 1, washed, and incubated. Supernatant was collected 24 h later. In IFN-α- and poly(I:C) (PIC)-pretreated astrocyte cultures, no viral progeny could be detected. In contrast, viral replication in U-87 cells was mildly attenuated by IFN and unaffected by poly(I:C).
