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. 2006 Nov 8;81(3):1274–1287. doi: 10.1128/JVI.00803-06

FIG. 7.

FIG. 7.

Growth of the ΔHVR2 and Δoct mutants in tissue culture. (A) Single-step growth kinetics. Confluent monolayers of 17Cl1 cells were infected with wild-type, ΔHVR2, or Δoct viruses at a multiplicity of infection (moi) of 4.0 PFU per cell. At the indicated times postinfection, aliquots of medium were removed and infectious titers were determined on mouse L2 cells. Open and solid symbols represent results from two independent experiments. (B) Growth following a low multiplicity of infection. Confluent monolayers of 17Cl1 cells were infected with wild-type or ΔHVR2 viruses at a multiplicity of 0.01 PFU per cell. At the indicated times postinfection, aliquots of medium were removed and infectious titers were determined on mouse L2 cells. Open and solid symbols represent results from two independent experiments.