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. 2006 Nov 22;81(3):1424–1432. doi: 10.1128/JVI.02054-06

TABLE 3.

50% neutralization endpoints for V2-specific MAbs C108g and 10/76b against YU2 Envs with modified V1 and V2 sequences

Envelope V1 region V2 region IC50 (μg/ml)
C108g 10/76b
131140 160167
YU2 LNCTDLRNATNTT GEIKNCSFNITTSIRDKVQKEYALFY >200 >200
YU2 (D167G) ------------- ---------------G---------- 0.24 11
YU2 (T133A/D167G) ---A--------- ---------------G---------- 0.057 2.6
YU2 (T133A/T142A/D167G) ---A--------A ---------------G---------- 0.0095 1.7
YU2 (T133A/T142A/T162A/D167G) ---A--------A ----------A----G---------- 7.7 0.033
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