TABLE 3.
50% neutralization endpoints for V2-specific MAbs C108g and 10/76b against YU2 Envs with modified V1 and V2 sequences
Envelope | V1 region | V2 region | IC50 (μg/ml)
|
|
---|---|---|---|---|
C108g | 10/76b | |||
131140 | 160167 | |||
YU2 | LNCTDLRNATNTT | GEIKNCSFNITTSIRDKVQKEYALFY | >200 | >200 |
YU2 (D167G) | ------------- | ---------------G---------- | 0.24 | 11 |
YU2 (T133A/D167G) | ---A--------- | ---------------G---------- | 0.057 | 2.6 |
YU2 (T133A/T142A/D167G) | ---A--------A | ---------------G---------- | 0.0095 | 1.7 |
YU2 (T133A/T142A/T162A/D167G) | ---A--------A | ----------A----G---------- | 7.7 | 0.033 |