FIG. 1.
Clinical results of inoculation of BALB/c pups with five strains of rotavirus. Newborn BALB/c pups were inoculated intraperitoneally with 1.5 × 106 FFU of the different strains of rotavirus on day 1 of life and monitored for 21 days. (A) Percentage of mice that developed clinical symptoms of hepatobiliary injury; (B) average daily weight of pups injected with the different strains of rotavirus; (C) survival of mice infected with the different strains of rotavirus. The mortality rate of pups inoculated with SA11-SM was 21%, which was significantly higher than that of mice injected with saline, EDIM, or Wa (*, P < 0.05). The mortality rates of mice injected with RRV and SA11-FM were 82% and 90%, respectively, which was significantly higher than that of mice injected with saline, EDIM, Wa, or SA 11-SM (+, P < 0.05).