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Model of sequential core phosphorylation and dephosphorylation regulating hepadnavirus reverse transcription. (1) Core phosphorylation during or after translation; (2) NC assembly and pgRNA packaging; (3) complete minus-strand DNA synthesis and initial stage of plus-strand DNA synthesis; (4) core dephosphorylation followed by plus-strand DNA maturation. K1 and K2, unknown cellular kinases; Pase, unknown cellular phosphatase. See the text for details.
