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. 2007 Feb 22;117(3):739–745. doi: 10.1172/JCI30400

Figure 1. PKCε ASO is effective and well tolerated.

Figure 1

(A) The amount of PKCε mRNA was determined by quantitative RT-PCR after 4 weeks of treatment with saline, a control ASO, and a specific ASO against PKCε (PKCε ASO). Data are expressed as relative to expression in saline. #P < 0.01 versus saline; ΧP < 0.001 versus control; ‡P < 0.01 versus control. (B) PKCε ASO specifically decreases PKCε protein levels in liver and epididymal white adipose tissue (WAT), but not in gastrocnemius. (C) Weight gain over 4 weeks of ASO therapy. Surgery was performed on rats between days 15 and 20.