FIG. 3.

Model for positive (phosphorylation) and negative (dephosphorylation) control of VanR by VanS and schematic representation of the synthesis of peptidoglycan precursors in VanA- or VanB-type strains. Kinase (A) and phosphatase (B) activities of VanS are depicted. K, heterologous kinase; R, regulator; S, sensor. Dotted blue circle, sensor domain; blue box, transmembrane domain; white circle, kinase domain; horizontally striped green circle, receiver domain; checkerboard green box, effector domain.