TABLE 4.

Treatment options for histoplasmosis

Agent	Description
Amphotericin B	Used for severe pulmonary or disseminated disease for a few wk until patient is improved; lipid formulations preferred, but cost is often prohibitive
Itraconazole	Preferred agent for mild to moderate pulmonary or disseminated disease; oral solution gives more consistent serum levels than capsules
Fluconazole	Second-line agent; not as efficacious as itraconazole
Ketoconazole	Rarely used because of toxicity
Voriconazole	May be effective; little clinical experience
Posaconazole	May be effective; little clinical experience
Echinocandins	Not active; should not be used