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Time-kill analysis of isolates treated with RWJ-416457 or linezolid at four times the MIC. Isolates were grown in control medium (♦), medium with RWJ-416457 (□), and medium with linezolid (•). Against MRSA OC 2878, the RWJ-416457 MIC was 1 μg/ml and the linezolid MIC was 2 μg/ml; against E. faecalis ATCC 51922, the RWJ-416457 MIC was 1 μg/ml and the linezolid MIC was 4 μg/ml.
