FIG. 2.

Effect of albicidin on relaxation of supercoiled DNA by topoisomerases E. coli DNA gyrase (10 nM) (A) and E. coli topoisomerase IV (5 nM) (B). Controls were no enzyme (lanes −), no drug (lanes +), and the known gyrase inhibitors ciprofloxacin (lanes CFX) and novobiocin (lanes NOV).